HLCS (NM_000411) Human Recombinant Protein
Product Specifications
Background
This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jun 2011]
Synonyms
HCS
Gene ID
3141
UniProt
P50747
Accession Number mRNA
NM_000411
Chromosomal Location
21q22.13
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Biotin metabolism, Metabolic pathways
Field of Research
Biotin metabolism, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
80.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
HLCS
Species
Human
Protein ID
NP_000402
Overview
Recombinant protein of human holocarboxylase synthetase (biotin- (proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing) ) ligase) (HLCS)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3141
Uniprot URL
https://www.uniprot.org/uniprot/P50747
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000411
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000402
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