JPT1 (NM_016185) Human Recombinant Protein
Product Specifications
Background
Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408) . Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422) . Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365) . Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408) .[UniProtKB/Swiss-Prot Function]
Synonyms
ARM2; HN1; HN1A
Gene ID
51155
UniProt
Q9UK76
Accession Number mRNA
NM_016185
Chromosomal Location
17q25.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
15.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
JPT1
Species
Human
Protein ID
NP_057269
Overview
Recombinant protein of human hematological and neurological expressed 1 (HN1), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/51155
Uniprot URL
https://www.uniprot.org/uniprot/Q9UK76
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016185
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057269
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