SETMAR (NM_006515) Human Recombinant Protein
Product Specifications
Background
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Synonyms
Mar1; METNASE
Gene ID
6419
UniProt
Q53H47, E7EN68
Accession Number mRNA
NM_006515
Chromosomal Location
3p26.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Lysine degradation
Field of Research
Lysine degradation
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
77.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SETMAR
Species
Human
Protein ID
NP_006506
Overview
Recombinant protein of human SET domain and mariner transposase fusion gene (SETMAR)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6419
Uniprot URL
https://www.uniprot.org/uniprot/Q53H47
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006515
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006506
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