SETMAR (NM_006515) Human Recombinant Protein

Product Specifications

Background

This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Overview

Recombinant protein of human SET domain and mariner transposase fusion gene (SETMAR)

Synonyms

Mar1; METNASE

Gene ID

6419

UniProt

Q53H47, E7EN68

Accession Number mRNA

NM_006515

Chromosomal Location

3p26.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Lysine degradation

Field of Research

Lysine degradation

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transcription Factors

Molecular Weight

77.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.