Von Willebrand Factor (VWF) (NM_000552) Human Recombinant Protein

Product Specifications

Background

This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]

Overview

Purified recombinant protein of Human von Willebrand factor (VWF), Ala23-End, with C-terminal His tag, secretory expressed in HEK293 cells, 50ug

Synonyms

F8VWF; VWD

Gene ID

7450

UniProt

P04275

Accession Number mRNA

NM_000552

Chromosomal Location

12p13.31

Expression System

HEK293

Tag

C-HIS

Related Pathways

Complement and coagulation cascades, ECM-receptor interaction, Focal adhesion

Field of Research

Complement and coagulation cascades, ECM-receptor interaction, Focal adhesion

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

PBS, pH7.4, 10% glycerol. Stable for at least 3 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Function

Druggable Genome, Secreted Protein

Molecular Weight

308.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.