Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Atxn3 (NM_001167914) Mouse Recombinant Protein

Product Specifications

Background

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity) . Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity) . Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:21855799) . Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity) . Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse ataxin 3 (Atxn3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

2210008M02Rik; AI463012; AI647473; ataxin-3; ATX3; Mjd; MJD1; Sca3

Gene ID

110616

UniProt

Q5M8S1, E9Q717, Q810M8

Accession Number mRNA

NM_001167914

Chromosomal Location

12 E

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

33.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

Atxn3

Species

Mouse

Protein ID

NP_001161386

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/110616

Uniprot URL

https://www.uniprot.org/uniprot/Q5M8S1

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001167914

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001161386

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

ADCK1 (Uncharacterized aarF Domain-containing Protein Kinase 1, FLJ39600) (HRP)
MBS6151100-01 0.1 mL

ADCK1 (Uncharacterized aarF Domain-containing Protein Kinase 1, FLJ39600) (HRP)

Ask
View Details
ADCK1 (Uncharacterized aarF Domain-containing Protein Kinase 1, FLJ39600) (HRP)
MBS6151100-02 5x 0.1 mL

ADCK1 (Uncharacterized aarF Domain-containing Protein Kinase 1, FLJ39600) (HRP)

Ask
View Details
EOLA1 (h) -PR
sc-91055-PR 10 µM - 20 µL

EOLA1 (h) -PR

Ask
View Details
Flavanone
HY-N7128-01 100 mg

Flavanone

Ask
View Details
Flavanone
HY-N7128-02 10 mM - 1 mL

Flavanone

Ask
View Details
Flavanone
HY-N7128-03 500 mg

Flavanone

Ask
View Details