Prkacb (NM_011100) Mouse Recombinant Protein
Product Specifications
Background
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:9368018) . Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
CbPKA; Pkacb
Gene ID
18749
UniProt
P68181
Accession Number mRNA
NM_011100
Chromosomal Location
3 H2
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
41.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Prkacb
Species
Mouse
Protein ID
NP_035230
Overview
Purified recombinant protein of Mouse protein kinase, cAMP dependent, catalytic, beta (Prkacb), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/18749
Uniprot URL
https://www.uniprot.org/uniprot/P68181
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_011100
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_035230
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