Sox10 (BC018551) Mouse Recombinant Protein
Product Specifications
Background
Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821) . Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821) . Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311) . Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
Dom; gt; Sox21
Gene ID
20665
UniProt
Q04888
Accession Number mRNA
BC018551
Chromosomal Location
15 37.7 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
49.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Sox10
Species
Mouse
Overview
Purified recombinant protein of Mouse SRY-box containing gene 10 (cDNA clone MGC:18351 IMAGE:3675437), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/20665
Uniprot URL
https://www.uniprot.org/uniprot/Q04888
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC018551
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