Telo2 (NM_001163661) Mouse Recombinant Protein
Product Specifications
Background
Regulator of the DNA damage response (DDR) . Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC) . Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
1200003M09Rik; AI415602; mKIAA0683; Tel2
Gene ID
71718
UniProt
Q9DC40
Accession Number mRNA
NM_001163661
Chromosomal Location
17 A3.3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
93.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Telo2
Species
Mouse
Protein ID
NP_001157133
Overview
Purified recombinant protein of Mouse telomere maintenance 2 (Telo2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/71718
Uniprot URL
https://www.uniprot.org/uniprot/Q9DC40
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001163661
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001157133
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