Cgas (NM_173386) Mouse Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Synonyms
E330016A19Rik; Mb21d1
Gene ID
214763
UniProt
Q8C6L5, Q8BSY1
Accession Number mRNA
NM_173386
Chromosomal Location
9 E1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
58.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Cgas
Species
Mouse
Protein ID
NP_775562
Overview
Purified recombinant protein of Mouse cyclic GMP-AMP synthase (Cgas), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/214763
Uniprot URL
https://www.uniprot.org/uniprot/Q8C6L5
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_173386
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_775562
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