CD27 (NM_001242) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Synonyms
S152; S152. LPFS2; T14; TNFRSF7; Tp55
Gene ID
939
UniProt
P26842
Accession Number mRNA
NM_001242
Chromosomal Location
12p13.31
Expression System
HEK293
Tag
C-DDK/His
Related Pathways
Cytokine-cytokine receptor interaction
Field of Research
Cytokine-cytokine receptor interaction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
21 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CD27
Species
Human
Protein ID
NP_001233
Overview
Purified recombinant protein of human CD27 molecule (CD27), with C-terminal DDK/His tag, expressed in human cells, 20 µg
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/939
Uniprot URL
https://www.uniprot.org/uniprot/P26842
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001242
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001233
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