TrkB (NTRK2) (NM_006180) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Overview

Recombinant protein of human neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant a, residues 32-430aa, with C-terminal DDK tag, expressed in sf9, 20ug

Synonyms

DEE58; EIEE58; GP145-TrkB; OBHD; trk-B; TRKB

Gene ID

4915

UniProt

Q16620, Q5VWE5, A0A024R230

Accession Number mRNA

NM_006180

Chromosomal Location

9q21.33

Expression System

Sf9

Tag

C-DDK

Related Pathways

MAPK signaling pathway, Neurotrophin signaling pathway

Field of Research

MAPK signaling pathway, Neurotrophin signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.

Function

Druggable Genome, Protein Kinase, Transmembrane

Molecular Weight

44.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.