TrkB (NTRK2) (NM_006180) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Synonyms
DEE58; EIEE58; GP145-TrkB; OBHD; trk-B; TRKB
Gene ID
4915
UniProt
Q16620, Q5VWE5, A0A024R230
Accession Number mRNA
NM_006180
Chromosomal Location
9q21.33
Expression System
Sf9
Tag
C-DDK
Related Pathways
MAPK signaling pathway, Neurotrophin signaling pathway
Field of Research
MAPK signaling pathway, Neurotrophin signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.
Function
Druggable Genome, Protein Kinase, Transmembrane
Molecular Weight
44.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NTRK2
Species
Human
Protein ID
NP_006171
Overview
Recombinant protein of human neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant a, residues 32-430aa, with C-terminal DDK tag, expressed in sf9, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4915
Uniprot URL
https://www.uniprot.org/uniprot/Q16620
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006180
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006171
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