RBPJK (RBPJ) (NM_005349) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
Synonyms
AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1; KBF2; RBP-J; RBP-JK; RBP-J kappa; RBPJK; RBPSUH; SUH
Gene ID
3516
UniProt
Q06330
Accession Number mRNA
NM_005349
Chromosomal Location
4p15.2
Expression System
E. coli
Tag
N-His
Related Pathways
Notch signaling pathway
Field of Research
Notch signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Function
Transcription Factors
Molecular Weight
55.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RBPJ
Species
Human
Protein ID
NP_005340
Overview
Purified recombinant protein of Human recombination signal binding protein for immunoglobulin kappa J region (RBPJ), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3516
Uniprot URL
https://www.uniprot.org/uniprot/Q06330
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005349
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005340
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