SPI1 (NM_001080547) Human Recombinant Protein
Product Specifications
Background
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of Human spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), transcript variant 1, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
OF; PU.1; SFPI1; SPI-1; SPI-A
Gene ID
6688
UniProt
P17947
Accession Number mRNA
NM_001080547
Chromosomal Location
11p11.2
Expression System
E. coli
Tag
N-His
Related Pathways
Acute myeloid leukemia, Pathways in cancer
Field of Research
Acute myeloid leukemia, Pathways in cancer
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Transcription Factors
Molecular Weight
31 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SPI1
Species
Human
Protein ID
NP_001074016
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6688
Uniprot URL
https://www.uniprot.org/uniprot/P17947
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001080547
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001074016
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