CSNK1G2 (NM_001319) Human Recombinant Protein
Product Specifications
Background
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.[UniProtKB/Swiss-Prot Function]
Synonyms
CK1g2
Gene ID
1455
UniProt
P78368
Accession Number mRNA
NM_001319
Chromosomal Location
19p13.3
Expression System
E. coli
Tag
N-GST and C-His
Related Pathways
Hedgehog signaling pathway
Field of Research
Hedgehog signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome, Protein Kinase
Molecular Weight
75.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CSNK1G2
Species
Human
Protein ID
NP_001310
Overview
Purified recombinant protein of Human casein kinase 1, gamma 2 (CSNK1G2), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1455
Uniprot URL
https://www.uniprot.org/uniprot/P78368
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001319
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001310
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