SNIP1 (NM_024700) Human Recombinant Protein

Product Specifications

Background

This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED) . [provided by RefSeq, Mar 2012]

Overview

Purified recombinant protein of Human Smad nuclear interacting protein 1 (SNIP1), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

PML1; PMRED

Gene ID

79753

UniProt

Q8TAD8, B1AK66

Accession Number mRNA

NM_024700

Chromosomal Location

1p34.3

Expression System

E. coli

Tag

N-GST and C-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.

Molecular Weight

73.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.