NOTCH3 Rabbit pAb (APR30364N)

Product Specifications

Background

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NOTCH3 Rabbit pAb (APR30364N) .

Synonyms

NOTCH3; CADASIL; CADASIL1; CASIL; IMF2; LMNS; notch 3

Gene ID

4854

UniProt

Q9UM47

Cellular Locus

Cell membrane, Nucleus, Single-pass type I membrane protein

Applications

IF (SW480) WB (HEK293T, DLD-1, Rattus norvegicus)

Dilution

WB 1:200 - 1:1000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 243kDa Observed MW: 90kDa/280kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.