RASGRP3 Mouse Monoclonal Antibody [Clone ID: LBI2C11]
Product Specifications
Background
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]) . [supplied by OMIM, Mar 2008]
Synonyms
GRP3
Gene Name
Homo sapiens RAS guanyl releasing protein 3 (RASGRP3), transcript variant 2, mRNA.
Gene ID
25780
UniProt
Q8IV61
Conjugation
Unconjugated
Related Pathways
B cell receptor signaling pathway, MAPK signaling pathway
Field of Research
B cell receptor signaling pathway, MAPK signaling pathway
Dilution
WB 1:2000, IHC 1:150
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
RASGRP3
Overview
Carrier-free (BSA/glycerol-free) RASGRP3 mouse monoclonal antibody, clone LBI2C11
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=25780
Uniprot URL
https://www.uniprot.org/uniprot/Q8IV61
Curated Selection
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