IL10RA Mouse Monoclonal Antibody [Clone ID: LBI1C12]

Product Specifications

Background

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

Overview

Carrier-free (BSA/glycerol-free) IL10RA mouse monoclonal antibody, clone LBI1C12

Synonyms

CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R

Gene Name

Homo sapiens interleukin 10 receptor subunit alpha (IL10RA), transcript variant 1, mRNA.

Gene ID

3587

UniProt

Q13651

Conjugation

Unconjugated

Related Pathways

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Field of Research

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Dilution

WB 1:1000

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome, Transmembrane

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.