GRF2 (RAPGEF1) Mouse Monoclonal Antibody [Clone ID: LBI2F5]
Product Specifications
Background
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Synonyms
C3G; GRF2
Gene Name
Homo sapiens Rap guanine nucleotide exchange factor 1 (RAPGEF1), transcript variant 2, mRNA.
Gene ID
2889
UniProt
Q13905
Conjugation
Unconjugated
Related Pathways
Focal adhesion, Insulin signaling pathway, Neurotrophin signaling pathway, Renal cell carcinoma
Field of Research
Focal adhesion, Insulin signaling pathway, Neurotrophin signaling pathway, Renal cell carcinoma
Dilution
WB 1:400~4000, IHC 1:150, IF 1:100
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
RAPGEF1
Overview
Carrier-free (BSA/glycerol-free) RAPGEF1 mouse monoclonal antibody, clone LBI2F5
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2889
Uniprot URL
https://www.uniprot.org/uniprot/Q13905
Curated Selection
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