GRF2 (RAPGEF1) Mouse Monoclonal Antibody [Clone ID: LBI2F5]

Product Specifications

Background

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Overview

Carrier-free (BSA/glycerol-free) RAPGEF1 mouse monoclonal antibody, clone LBI2F5

Synonyms

C3G; GRF2

Gene Name

Homo sapiens Rap guanine nucleotide exchange factor 1 (RAPGEF1), transcript variant 2, mRNA.

Gene ID

2889

UniProt

Q13905

Conjugation

Unconjugated

Related Pathways

Focal adhesion, Insulin signaling pathway, Neurotrophin signaling pathway, Renal cell carcinoma

Field of Research

Focal adhesion, Insulin signaling pathway, Neurotrophin signaling pathway, Renal cell carcinoma

Dilution

WB 1:400~4000, IHC 1:150, IF 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.