RNF20 Mouse Monoclonal Antibody [Clone ID: LBI2B9]

Product Specifications

Background

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS) . [provided by RefSeq, Feb 2012]

Overview

RNF20 mouse monoclonal antibody, clone LBI2B9

Synonyms

BRE1; BRE1A; hBRE1

Gene Name

Ring finger protein 20

Gene ID

56254

UniProt

Q5VTR2

Conjugation

Unconjugated

Concentration

1 mg/ml

Dilution

WB 1:500, IHC 1:150

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.