APC Mouse Monoclonal Antibody [Clone ID: LBI2B8]
Product Specifications
Background
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
Synonyms
BTPS2; DP2; DP2.5; DP3; GS; PPP1R46
Gene Name
Adenomatous polyposis coli
Gene ID
324
UniProt
P25054
Conjugation
Unconjugated
Related Pathways
Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway
Field of Research
Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
APC
Overview
APC mouse monoclonal antibody, clone LBI2B8
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=324
Uniprot URL
https://www.uniprot.org/uniprot/P25054
Curated Selection
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