MBD2 Antibody (N-term) [APR30659G]

Product Specifications

Background

Tissue Location: Highly expressed in brain, heart, kidney, stomach, testis and placenta.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MBD2 Antibody (N-term) [APR30659G].

Synonyms

Methyl-CpG-binding domain protein 2, Demethylase, DMTase, Methyl-CpG-binding protein MBD2, MBD2

Gene Name

HGNC:6917

Gene ID

8932

UniProt

Q9UBB5

Chromosomal Location

Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.