MBD2 Antibody (N-term) [APR30659G]
Product Specifications
Background
Tissue Location: Highly expressed in brain, heart, kidney, stomach, testis and placenta.
Synonyms
Methyl-CpG-binding domain protein 2, Demethylase, DMTase, Methyl-CpG-binding protein MBD2, MBD2
Gene Name
HGNC:6917
Gene ID
8932
UniProt
Q9UBB5
Chromosomal Location
Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Molecular Weight
43255
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MBD2 Antibody (N-term) [APR30659G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8932
Uniprot URL
https://www.uniprot.org/uniprot/Q9UBB5
Available Sizes
Curated Selection
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