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PRPS2 Protein, Human, Recombinant (His Tag)

Product Specifications

Background

PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway. The gene for PRS II (PRPS2) is located at a different region of the X chromosome, namely Xpter-a21. The promoter region of the human PRPS2 gene was also GC-rich and contained a TATA-like sequence, four Sp1 binding sites and a homopyrimidine stretch.

Overview

A DNA sequence encoding the human PRPS2 (P11908-1) (Met1-Leu318) was expressed with a C-terminal polyhistidine tag.

Synonyms

PRPS2 Protein, Human; PRSII Protein, Human

Gene Name

Phosphoribosyl pyrophosphate synthetase 2

UniProt

P11908-1

Expression System

E. coli

Tag

C-His

Endotoxin

Please contact us for more information.

Purity

> 95 % as determined by SDS-PAGE.

Activity

Kinase activity untested

Form

Liquid

Buffer

Supplied as sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.

Molecular Weight

The recombinant human PRPS2 comprises 324 amino acids and has a predicted molecular mass of 35.6 kDa. The apparent molecular mass of the protein is approximately 36 kDa in SDS-PAGE under reducing conditions.

Storage Conditions

Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PRPS2

Species

Human

Uniprot URL

https://www.uniprot.org/uniprot/P11908-1

AA Sequence

Met1-Leu318

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