KLRB1 Antibody: HRP (OABF01101-HRP)
Product Specifications
Gene Name
Killer cell lectin-like receptor subfamily B, member 1
Gene Aliases
NKR, CD161, CLEC5B, NKR-P1, NKRP1A, NKR-P1A, hNKR-P1A
Gene ID
3820
Swiss Prot
Q12918
Host
Rabbit
Reactivity
Human
Immunogen
KLH conjugated synthetic peptide derived from human CD161/NK11
Target
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha (1,3) Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB, FC, IHC-P, IF
Purification
Purified by Protein A.
Concentration
0.6-0.7 mg/mL
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Shipping Conditions
Wet Ice
Fragment
IgG
NCBI Gene Symbol
KLRB1
Curated Selection
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