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PDE4B Antibody - middle region : FITC (ARP56256_P050-FITC)

Product Specifications

Gene Name

Phosphodiesterase 4B, cAMP-specific

Gene Aliases

DPDE4, PDEIVB

Gene ID

5142

Swiss Prot

Q5TEK5

Accession Number

NP_001032416

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PDE4B

Target

The specific function of this protein remains unknown.This gene is a member of the type IV, cyclic AMP (cAMP) -specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Partner Proteins

MAGEA11; RCBTB2; APOA1; ALB; PAFAH1B1; UBC; DISC1; PRKACA

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 83%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 93%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

64kDa

References & Citations

Fatemi, S.H., Schizophr. Res. 101 (1-3), 36-49 (2008)

Shipping Conditions

Wet Ice

Product Datasheet

Anti-PDE4B (ARP56256_P050-FITC) antibody

Protein Length

564

NCBI Gene Symbol

PDE4B

NCBI GB Accession Number

PDE4B

Host or Source

Rabbit

Protein Name

Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila) EMBL CAI21750.1

Nucleotide Accession Number

NM_001037339

Peptide Sequence

QDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED

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