Nr1h3 Antibody - C-terminal region : HRP (ARP32674_P050-HRP)
Product Specifications
Gene Name
Nuclear receptor subfamily 1, group H, member 3
Gene Aliases
Un, LXR, RLD1, Unr1, AU018371
Gene ID
22259
Swiss Prot
Q9Z0Y9
Accession Number
NP_038867
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit
Target
Nr1h3 is an orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Nr1h3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
Partner Proteins
Ncor1; Ppargc1b; Zfp111; Rxrg; Rxra; Ppargc1a; Ubc
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
50kDa
Shipping Conditions
Wet Ice
Product Datasheet
Anti-Nr1h3 (ARP32674_P050-HRP) antibody
Protein Length
445
NCBI Gene Symbol
NR1H3
NCBI GB Accession Number
Nr1h3
Host or Source
Rabbit
Protein Name
Oxysterols receptor LXR-alpha
Nucleotide Accession Number
NM_013839
Peptide Sequence
LLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDPLMFPRM
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