WB518

WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod (HY-B0180) and TPA (HY-18739) -induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17[1].

Product Specifications

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/wb518.html

Concentration

10mM

Purity

96.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C1CN(CC2=C1C(C#N)=C(S2)NC(C3=CN(N=C3)C)=O)C(C4=CC=C(O4)Br)=O)=O

Molecular Formula

C20H16BrN5O5S

Molecular Weight

518.34

References & Citations

[1]Ti C, et al. WB518, a novel STAT3 inhibitor, effectively alleviates IMQ and TPA-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17. Int Immunopharmacol. 2024 Jan 25;127:111344.