Nicotinamide-d4
Product Specifications
UNSPSC Description
Nicotinamide-d4 is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Target Antigen
Endogenous Metabolite; Sirtuin
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
Field of Research
Neurological Disease; Cancer
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[2H]C1=C([2H])C([2H])=C(C(N)=O)C([2H])=N1
Molecular Weight
126.15
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. ;Bhansali SG, et al. Nicotinamide prevents apoptosis in human cortical neuronal cells. Toxicol Mech Methods. 2006;16(4):17|[2]Bhansali SG, et al. Nicotinamide prevents apoptosis in human cortical neuronal cells. Toxicol Mech Methods. 2006;16(4):173-80.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information
No Development Reported
CAS Number
347841-88-7
Available Sizes
Curated Selection
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