Animal-Free TGF beta 1/TGFB1, Human (His)

Approximately 10 kDa (mature TGFβ1) & 40 kDa (LAP protein) & 50 kDa (inacitve latent TGFβ1), based on SDS-PAGE under reducing conditions, due to the glycosylation.

[1]Ghadami M, et al. Genetic mapping of the Camurati-Engelmann disease locus to chromosome 19q13.1-q13.3. Am J Hum Genet. 2000 Jan;66 (1) :143-7.|[2]Vaughn SP, et al. Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. Genomics. 2000 May 15;66 (1) :119-21.|[3]Chen Q, et al. Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1. PLoS One. 2014 Oct 13;9 (10) :e108528.|[4]Kotlarz D, et al. Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy. Nat Genet. 2018 Mar;50 (3) :344-348.|[5]Hwangbo C, et al. Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene. 2016 Jan 21;35 (3) :389-401.|[6]Letterio JJ, rt al. Regulation of immune responses by TGF-beta. Annu Rev Immunol. 1998;16:137-61.