FOXO4-DRI

FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells[1].

Product Specifications

CAS Number

[2460055-10-9]

UNSPSC

12352209

Target

Apoptosis; MDM-2/p53

Type

Peptides

Related Pathways

Apoptosis

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/foxo4-dri.html

Purity

99.93

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H]([C@@H](O)C)C(N[C@H](CC(C)C)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@H](CCC(O)=O)C(N1[C@H](CCC1)C(N[C@H](C)C(N[C@H](CO)C(N[C@H](CCC(O)=O)C(N[C@H]([C@H](C)CC)C(N[C@H](C)C(N[C@H](CCC(N)=O)C(N[C@H](CO)C(N[C@H]([C@H](C)CC)C(N[C@H](CC(C)C)C(N[C@H](CCC(O)=O)C(N[C@H](C)C(N[C@H](CC2=CC=C(C=C2)O)C(N[C@H](CO)C(N[C@H](CCC(N)=O)C(N[C@H](CC(N)=O)C(NCC(N[C@H](CC3=CNC4=CC=CC=C34)C(N[C@H](C)C(N[C@H](CC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CO)C(NCC(NCC(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(N5[C@H](CCC5)C(N6[C@H](CCC6)C(N7[C@H](CCC7)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CC(C)C)N

Molecular Formula

C228H388N86O64

Molecular Weight

5358.06

References & Citations

[1]Zhang C, et al. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY) . 2020 Jan 20;12 (2) :1272-1284.|[2]Huang Y, et al. Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes. Front Bioeng Biotechnol. 2021 Apr 29;9:677576.