PX-866-17OH
Product Specifications
UNSPSC Description
PX-866-17OH is the metabolite of PX-866 (Sonolisib, HY-N6775) and a pan-isoform inhibitor of PI3K with IC50s of 14, 57, 131, and 148 nM against PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ, respectively[1].
Target Antigen
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/px-866-17oh.html
Smiles
C[C@@]12C3=C(C(C(O)=C1/C(C(O[C@@H]2COC)=O)=C\N(CC=C)CC=C)=O)[C@@]4([H])[C@](C[C@H]3OC(C)=O)([C@H](CC4)O)C
Molecular Weight
527.61
References & Citations
[1]Zask A, et al. Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113572/PX-866-17OH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113572/
Clinical Information
No Development Reported
CAS Number
1012327-63-7
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