Propiolactone

Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL) [1][2].

Product Specifications

CAS Number

[57-57-8]

Product Name Alternative

β-propiolactone; 2-Oxetanone; Betaprone

UNSPSC

12352005

Hazard Statement

H227, H315, H319, H330, H350

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/propiolactone.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1OCC1

Molecular Formula

C3H4O2

Molecular Weight

72.06

Precautions

H227, H315, H319, H330, H350

References & Citations

[1]Roberts A, et al. Immunogenicity and protective efficacy in mice and hamsters of a β-propiolactone inactivated whole virus SARS-CoV vaccine. Viral Immunol. 2010 Oct;23 (5) :509-19|[2]Kulkarni R, et al. Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA. J Virol Methods. 2021 Jan;287:113996.