CC-115
CC-115 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.
Product Specifications
CAS Number
[1228013-15-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA-PK; mTOR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CC-115.html
Purity
99.82
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2
Molecular Formula
C16H16N8O
Molecular Weight
336.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Mortensen DS, et al. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58 (14) :5599-5608.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MTOR; mTORC1; mTORC2
Citation 01
Front Pharmacol. 2020 Nov 11;11:580407.|Sci Data. 2024 Sep 19;11 (1) :1024.|Front Pharmacol. 2020 Nov 11;11:580407.
Available Sizes
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