IDD388
IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC50 of 30 nM. IDD388 displays selectivity for ALR2 over ALR1 (IC50 of 14 μM) [1].
Product Specifications
CAS Number
[314297-26-2]
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/idd388.html
Purity
99.40
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(COC1=CC(Cl)=CC=C1C(NCC2=CC=C(C=C2F)Br)=O)O
Molecular Formula
C16H12BrClFNO4
Molecular Weight
416.63
References & Citations
[1]Holger Steuber, et al. Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. J Mol Biol. 2008 Jun 20;379 (5) :991-1016.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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