CSF1R, Cynomolgus (HEK293, His)

CSF1R is colony-stimulating factor receptor, a type I transmembrane protein receptor. Binding of CSF1R to CSF-1 or IL-34 activates a cascade of extracellular pro-cell survival kinases, including PI3K, ERK1/2, and JNK. CSF1R also recruits multiple downstream effector proteins/pathways, including PI3K, Grb2, SFK, Src, PKC, etc. CSF1R is involved in embryonic development and tissue repair and is associated with tumorigenesis and cancer progression. CSF1R Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CSF1R protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CSF1R Protein, Cynomolgus (HEK293, His) is 498 a.a., with molecular weight of 80-120 kDa.

IPVIEPSGPE LVVKPGETVT LRCVGNGSVE WDGPISPHWT LYSDGPSSVL TTNNATFQNT RTYRCTEPGD PLGGSAAIHL YVKDPARPWN VLAKEVVVFE DQDALLPCLL TDPVLEAGVS LVRLRGRPLL RHTNYSFSPW HGFIIHRAKF IQGQDYQCSA LMGGRKVMSI SIRLKVQKVI PGPPALTLVP AELVRIRGEA AQIVCSASNI DVDFDVFLQH NTTKLAIPQR SDFHDNRYQK VLTLSLGQVD FQHAGNYSCV ASNVQGKHST SMFFRVVESA YLDLSSEQNL IQEVTVGEGL NLKVMVEAYP GLQGFNWTYL GPFSDHQPEP KLANATTKDT YRHTFTLSLP RLKPSEAGRY SFLARNPGGW RALTFELTLR YPPEVSVIWT SINGSGTLLC AASGYPQPNV TWLQCAGHTD RCDEAQVLQV WVDPHPEVLS QEPFQKVTVQ SLLTAETLEH NQTYECRAHN SVGSGSWAFI PISAGARTHP PDEFLFTP