Gallocyanine (chloride)

Gallocyanine chloride is a synthetic blue dyestuff that can be used as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies. Gallocyanine chloride inhibits DKK1/LRP6 interaction (IC50=6.38 μM), activates Wnt signaling pathway, and causes β-catenin accumulation. Gallocyanine chloride exhibits anti-metastasis, anti-inflammatory and anti-fibrosis activities. Gallocyanine chloride can be used as a fluorescent probe for detection of superoxide anion radicals[1][2][3][4].

Product Specifications

CAS Number

[1562-85-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fluorescent Dye; Wnt; β-catenin

Type

Reference compound

Related Pathways

Others; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gallocyanine-chloride.html

Purity

92.00

Solubility

DMSO : 11.67 mg/mL (ultrasonic)

Smiles

OC1=C(O)C=C(C(O)=O)C2=C1[O+]=C3C=C(N(C)C)C=CC3=N2.[Cl-]

Molecular Formula

C15H13ClN2O5

Molecular Weight

336.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Thysiadis S, et al., Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer's disease. Bioorg Chem. 2018 Oct;80:230-244.|[2]Wu M, et al., Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis. Nat Commun. 2022 Mar 16;13 (1) :1371.|[3]Yang L, et al., Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Cell Death Dis. 2020 Oct 4;11 (10) :827.|[4]Panasenko O M, et al. Gallocyanine as a Fluorogen for the Identification of NADPH-Dependent Production of Superoxide Anion Radical by Blood Cells[J]. Russian Journal of Bioorganic Chemistry, 2021, 47: 299-306.