Midodrine

Midodrine is a selective and orally active adrenergic α1-receptor agonist. Midodrine can strengthen vascular contraction. Midodrine can be used for the researches of cardiovascular disease, such as orthostatic hypotension[1][2][3].

Product Specifications

CAS Number

[42794-76-3]

Product Name Alternative

(±) -Midodrin

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Midodrine.html

Purity

99.67

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NCC(C1=CC(OC)=CC=C1OC)O)CN

Molecular Formula

C12H18N2O4

Molecular Weight

254.28

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Criscuoli M, et al. Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice. Br J Pharmacol. 1988 Jan;93 (1) :132-8.|[2]Inchan A, et al. Anti-hypotensive effect of "Yahom Navakot" in rats with orthostatic hypotension. J Tradit Complement Med. 2021 Aug 3;12 (2) :180-189.|[3]Lee YJ, et al. Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ. PPAR Res. 2020 Feb 1;2020:3785137.