Cholic acid

Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active[1][2].

Product Specifications

CAS Number

[81-25-4]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Cholic_acid.html

Concentration

10mM

Purity

99.55

Solubility

0.1 M NaOH : 33.33 mg/mL (ultrasonic; adjust pH to 9 with NaOH) |DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL

Smiles

C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C

Molecular Formula

C24H40O5

Molecular Weight

408.57

Precautions

H315, H319

References & Citations

[1]Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684.|[2]Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45 (4) :346-352.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Human Endogenous Metabolite

Citation 01

Adv Sci (Weinh) . 2025 Feb 3:e2411719.|Aquaculture. 2023 Sep 18, 740123.|Cancer Cell. 2024 Aug 12;42 (8) :1386-1400.e8.|Cell Host Microbe. 2024 Feb 14;32 (2) :191-208.e9.|Cell Host Microbe. 2025 Aug 19:S1931-3128 (25) 00291-4.|Cell Res. 2019 Mar;29 (3) :193-205. |Front Cell Dev Biol. 2022 Jul 22:10:854425.|J Adv Res. 2024 Sep 5:S2090-1232 (24) 00389-8.|J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2501743.|J Pharm Biomed Anal. 2025 Jul 15:259:116760.|J Transl Med. 2024 Dec 20;22 (1) :1124.|J Voice. 2025 Nov 29:S0892-1997 (25) 00490-4.|Microb Pathog. 2026 Jan:210:108187.|Mol Neurobiol. 2024 Nov;61 (11) :9302-9319.|Nature. 2025 Jul;643 (8070) :192-200.|Research (Wash D C) . 2025 Jun 24:8:0741. |Transl Cancer Res. 2025 Aug 31;14 (8) :4774-4790.|Adv Mater. 2025 Apr;37 (17) :e2416349.|Cell Rep. 2025 Sep 17;44 (10) :116306.