Simufilam (hydrochloride)

Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. Simufilam hydrochloride restores NMDAR signaling and Arc expression. Simufilam hydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam hydrochloride can be used for research of Alzheimer's disease[1][2][3].

Product Specifications

CAS Number

[2480226-07-9]

Product Name Alternative

PTI-125 (hydrochloride)

UNSPSC

12352005

Target

Amyloid-β; iGluR; mTOR; Tau Protein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/simufilam-hydrochloride.html

Purity

99.85

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl

Molecular Formula

C15H22ClN3O

Molecular Weight

295.81

References & Citations

[1]Wang HY, et al. Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes. Front Aging. 2023 Jun 29;4:1175601. |[2]Wang HY, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012 Jul 18;32 (29) :9773-84. |[3]Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017 Jul;55:99-114.