Pyrazinamide

Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

Product Specifications

CAS Number

[98-96-4]

Product Name Alternative

Pyrazinecarboxamide; Pyrazinoic acid amide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Autophagy; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pyrazinamide.html

Purity

99.97

Solubility

DMSO : ≥ 50 mg/mL|H2O : 6.67 mg/mL (ultrasonic)

Smiles

O=C(C1=NC=CN=C1)N

Molecular Formula

C5H5N3O

Molecular Weight

123.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181 (7) :2044-9.|[2]Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2 (4) :MGM2-0023-2013.