Qstatin
QStatin is a potent and selective inhibitor of SmcR (V. harveyi LuxR homologue) with an EC50 of 208.9 nM, binding tightly to SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity. QStatin shows pan-QS (Vibrio quorum sensing) inhibitor activity in diverse Vibrio species and attenuates their virulence in an aquatic host. QStatin may be a sustainable antivibriosis agent useful in aquacultures[1].
Product Specifications
CAS Number
[902688-24-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/qstatin.html
Concentration
10mM
Purity
99.56
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=S(N1N=CC=C1)(C2=CC=C(Br)S2)=O
Molecular Formula
C7H5BrN2O2S2
Molecular Weight
293.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim BS, et al. QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species. MBio. 2018 Jan 30;9 (1) . pii: e02262-17.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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