IQ-3

IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively[1].

Product Specifications

CAS Number

[312538-03-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/iq-3.html

Purity

99.38

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2)C5=CC=CO5

Molecular Formula

C20H11N3O3

Molecular Weight

341.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Igor A Schepetkin, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81 (6) :832-45.