L748337

L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively[1]. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6[2]. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases[1][2][3].

Product Specifications

CAS Number

[244192-94-7]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/l748337.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 30 mg/mL (ultrasonic; warming)

Smiles

CC(NCC1=CC=CC(OC[C@@H](O)CNCCC2=CC=C(NS(=O)(C3=CC=CC=C3)=O)C=C2)=C1)=O

Molecular Formula

C26H31N3O5S

Molecular Weight

497.61

References & Citations

[1]S Neidhold, et al. The function of alpha- and beta-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. Br J Pharmacol. 2007 Feb;150 (3) :261-70.|[2]Masaaki Sato, et al. The beta3-adrenoceptor agonist 4-[[ (Hexylamino) carbonyl]amino]-N-[4-[2-[[ (2S) -2-hydroxy-3- (4-hydroxyphenoxy) propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S) -N-[4-[2-[[3-[3- (acetamidomethyl) phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor. Mol Pharmacol. 2008 Nov;74 (5) :1417-28.|[3]Ziwen Wang, et al. The protective effects of the β3 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) . Mol Med. 2020 Jun 5;26 (1) :54.