D-Cycloserine

D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research[1][2].

Product Specifications

CAS Number

[68-41-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; iGluR

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/D-Cycloserine.html

Purity

99.97

Solubility

DMSO : 1 mg/mL (warming) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1[C@H](N)CON1

Molecular Formula

C3H6N2O2

Molecular Weight

102.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Nitsche, M.A., et al., Consolidation of human motor cortical neuroplasticity by D-cycloserine. Neuropsychopharmacology, 2004. 29 (8) : p. 1573-8.|[2]Levin, E.D., et al., D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response. Pharmacol Biochem Behav, 2011. 98 (2) : p. 210-4.|[3]Sarah Batson, et al. Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nat Commun. 2017 Dec 5;8 (1) :1939.