Dimethoate

Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces reactive oxygen species (ROS) . Dimethoate induces DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice[1][2][3].

Product Specifications

CAS Number

[60-51-5]

UNSPSC

12352211

Hazard Statement

H301+H311

Target

Apoptosis; Cholinesterase (ChE) ; Insecticide; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dimethoate.html

Purity

99.91

Solubility

H2O : 10 mg/mL (ultrasonic)

Smiles

S=P(OC)(SCC(NC)=O)OC

Molecular Formula

C5H12NO3PS2

Molecular Weight

229.26

Precautions

H301+H311

References & Citations

[1]Martínez-Morcillo S, et al. The organophosphorus pesticide dimethoate decreases cell viability and induces changes in different biochemical parameters of rat pancreatic stellate cells. Toxicol In Vitro. 2019 Feb;54:89-97.|[2]Nazam N, et al. Dimethoate Induces DNA Damage and Mitochondrial Dysfunction Triggering Apoptosis in Rat Bone-Marrow and Peripheral Blood Cells. Toxics. 2020 Oct 1;8 (4) :80.|[3]Aly NM, et al. Effect of dimethoate on the immune system of female mice. J Environ Sci Health B. 2000 Jan;35 (1) :77-86.