Memantine

Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD) [1][2][3].

Product Specifications

CAS Number

[19982-08-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/memantine.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

N[C@]12C[C@@]3(C)C[C@](C2)(C)C[C@@H](C1)C3

Molecular Formula

C12H21N

Molecular Weight

179.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Marotta G, et al. Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. Molecules. 2020;25 (17) :4005. Published 2020 Sep 2. |[2]Pinho J, et al. Enhanced LTP in aged rats: Detrimental or compensatory?. Neuropharmacology. 2017;114:12-19. |[3]Moriguchi S, et al. Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice. Neuroscience. 2020;442:264-273.