Glu-AMS (TEA)

Glu-AMS TEA is a competitive inhibitor of Escherichia coli glutamyl-tRNA synthetase (GluRS), with the Ki of 2.8 nM[1].

Product Specifications

CAS Number

[1810728-44-9]

UNSPSC

12352005

Target

Aminoacyl-tRNA Synthetase; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/glu-ams-tea.html

Purity

90.15

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCN(CC)CC.O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O[C@@H]1COS(NC([C@@H](N)CCC(O)=O)=O)(=O)=O

Molecular Formula

C21H36N8O9S

Molecular Weight

576.62

References & Citations

[1]Sébastien P Blais, et al. tRNAGlu Increases the Affinity of Glutamyl-tRNA Synthetase for Its Inhibitor Glutamyl-Sulfamoyl-Adenosine, an Analogue of the Aminoacylation Reaction Intermediate Glutamyl-AMP: Mechanistic and Evolutionary Implications. PLoS One. 2015 Jun 3;10 (6) :e0130238.