β-NETA

β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC50=76 μM) and cholinesterase (ChE; IC50=40 μM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; IC50=1 mM) [1][2].

Product Specifications

CAS Number

[31059-54-8]

UNSPSC

12352005

Target

Apoptosis; Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/beta-neta.html

Purity

98.0

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2C=CC=CC2=C1)CC[N+](C)(C)C.[I-]

Molecular Formula

C16H20INO

Molecular Weight

369.24

References & Citations

[1]Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2- (alpha-naphthoyl) ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep;20 (9) :751-71.|[2]B V Sastry, et al. 2- (alpha-Naphthoyl) ethyltrimethylammonium iodide and its beta-isomer: new selective, stable and fluorescent inhibitors of choline acetyltransferase. J Pharmacol Exp Ther. 1988 Apr;245 (1) :72-80.