NSC319726
NSC319726 (ZMC1) is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM) ; shows no inhibition for p53 wild-type cells.
Product Specifications
CAS Number
[71555-25-4]
Product Name Alternative
ZMC1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC319726.html
Purity
99.60
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
C/C(C1=NC=CC=C1)=N\NC(N2CCC2)=S
Molecular Formula
C11H14N4S
Molecular Weight
234.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Yu X, et al. Allele-specific p53 mutant reactivation. Cancer Cell. 2012 May 15;21 (5) :614-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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